Zen-Bio, Inc.
3200 Chapel Hill-Nelson Blvd., Suite 102
Research Triangle Park, NC 27709
Ph: (919) 547-0692
Fax: (919) 547-0693William O. Wilkison, Ph.D., President
Yuan-Di Halvorsen, Ph.D., VP R&D
Peter Pieraccini, Business Manager
Product Line or Service As the core of the companys
platform technology, Zen-Bio has developed and mass-produces a human cultured adipocyte
cell system that retains many of the characteristics of mature adipocytes found in the
human body.
Technology/Proprietary Rights Drug-induced Adipose Secreted
Factors (Filed 12/97), Osteoblast Differentiation (Filed 12/97), Cell Culture Transport
System (Issued 3/98), Improved Human Adipocyte Culture system (Filed 5/98),
Adipocyte-selective Calcium Antagonists (Filed 4/98), Adipocyte cDNA Array (To be Filed
6/98), Leptin ELISA (To be Filed 6/98).
Market Opportunities By exploiting its unique platform
technology of human adipocyte biology, Zen-Bio is in the early stages of developing
intellectual property for detection and treatment of obesity, diabetes, osteoporosis, and
cardiovascular disease. The pharmaceutical industry spends nearly $20 billion annually to
develop alliances with emerging biotechnology companies like Zen-Bio. By utilizing
screening, gene/protein databases, and innovative target identification with its platform
human adipocyte technology, Zen-Bio is leveraging its expertise in adipocyte biology to
generate intellectual property for outlicensing to or co-development with large
pharmaceutical companies. A pertinent example is the licensing of the leptin gene (an
adipocyte-specific gene) from Rockefeller University to Amgen for $90 million dollars in
upfront and milestone fees.
Marketing/Sales and Distribution We have created the human
adipocyte market and have built a corporate network of over 75 customers. To increase our
volume, we have a marketing and distribution agreement with Stratagene, a biotechnology
supply company with a well-developed marketing and sales group. We are also negotiating
with a major cell culture company for additional proprietary products to be distributed.
Competition At the present time, Zen-Bio, Inc. enjoys pioneer
status in the human adipocyte field. Many companies are using mouse adipocyte systems to
attempt to discover drugs. No company is solely focused on the use of human adipocyte
biology to exploit these targets. One nascent company (Adipogenics) is starting an
adipocyte biology program for discovery. We believe others will enter this arena to take
advantage of the largely uncharted area of human adipocyte biology. Zen-Bio, Inc. has a
considerable edge in scientific expertise, lead time, proprietary information, tissue
sources, and customer/collaborator contacts. We need to exploit this lead NOW to maximize
our market domination.
Financial The following income projections include revenue and
expenses from all of the research initiatives mentioned in this business plan. We have
taken the lowest value of our market analyses for the revenue estimates and therefore, the
projection is considered conservative. |